tandem
Tandem Talk, Volume 1, issue 1
Choosing the right infusion set
By Sara McMillan, RN, CDCES; Jennifer Filler, MPH, RD, CDCES
 lady helping boy with infusion set

Choosing the right infusion set for the t:slim X2 insulin pump is just as important as selecting the right insulin pump.

Making sure you have the best infusion set for your body is key to ensuring success with insulin pump therapy. Over time, you may need to try alternative infusion sets to account for changes in your body or lifestyle.

Keep in mind that even the most advanced technology on the market cannot overcome issues with infusion sets. Yet, a significant benefit of a tubing pump is that you have numerous infusion set options to customize your pumping experience and optimize glycemic outcomes.

infusion set
Infusion Set Overview

Life is better with options. You can choose from five different infusion sets with a wide range of colors and tubing lengths that create more than 30 mix-and-match options.

steel needle

TruSteel Infusion Set

The TruSteel infusion set is an excellent option for many. The steel needle reduces the risk of encountering an occlusion or interrupting insulin delivery. The manual insertion requires minimal grip strength or dexterity, which makes for easy insertion. This set also has an extra adhesive pad, which will keep it securely in place, and should be changed every one to two days or as recommended by your healthcare provider (HCP).

This set is great for people who are new to pumping, very active or athletic, or at higher risk of extreme hyperglycemia (DKA).

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soft canulas

AutoSoft XC Infusion Set

The AutoSoft XC infusion set offers an automatic insertion device, multiple cannula length options, and a comfortable grip for easy disconnection. It can be inserted with one hand, which allows for multiple placement options (such as the back of the arm, upper buttocks, or lower back). This set is also available in three colors and should be changed every two to three days.

We recommend that you have an adequate amount of subcutaneous tissue (can you pinch an inch?) and reasonable grip strength to use this set.

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AutoSoft 90 Infusion Set

The AutoSoft 90 infusion set is very similar to the AutoSoft XC. Both have an automatic insertion device and multiple cannula lengths. The main difference is the AutoSoft 90 has a larger grip area that is also reversible for easy disconnection. Everything else is the same.

We recommend that you have an adequate amount of subcutaneous tissue (can you pinch an inch?) and reasonable grip strength to use this set.

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AutoSoft 30 Infusion Set

The AutoSoft 30 infusion set has an automatic insertion device, a window to see the insertion point, and a large, reversible grip for easy disconnection. The insertion process for this set requires two hands and should be changed every two to three days.

This set works well for individuals who are lean, active, or have issues with 90-degree cannulas. The soft cannula stays more shallow under the skin, helping to avoid ‘bumping’ into muscle, which could bend a soft cannula. The longer cannula sitting shallow under the skin is also less likely to bend with movement.

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Varisoft Infusion Set

The VariSoft infusion set works well for people who prefer the control of manual insertion. There is a window to see the insertion point, an audible click for reassurance of a good connection, and a large adhesive for extra security. The insertion process for this set requires two hands and it should be changed every two to three days.

The variable angle options allow you to customize the insertion depth based on your body type. Variable angles will allow for shallow insertion on lean areas of the body, and deeper insertion on areas with more subcutaneous tissue. The longer cannula options will also allow you to push past existing scar tissue that may be present.

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clinical advice
Clinical Advice
Have you ever thought?

“But I’ve used the same infusion set for 10 years — why am I suddenly having trouble?”

“I’m only getting one and a half days out of my
infusion sets before they fail!”

“My cannula bends at least once a week — what’s wrong with these infusion sets?”

“My pump is broken because my blood sugars are high. It must not be giving me the insulin.”

These sentiments can be common, especially for long-time insulin pumpers. Even with diligent infusion site rotation, scar tissue can build up over time, causing problems with occlusions, unexplained hyperglycemia, erratic blood glucose, and site discomfort.

Start by doing your own skin assessment. This can help identify scar tissue, inflamed tissue, or swelling/lumps. It can also help identify additional areas for insertion.

Other options include different cannula lengths, insertion angles, or material types (steel vs. soft cannula).

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clinical advice
Additional Considerations to Improve Outcomes
cream
Consider barrier wipes, “undertape,” or topical steroid cream or spray to improve skin irritation (under the direction of your HCP).
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When irritation is isolated to cannula insertion spot (e.g., red bumps), consider switching between a soft cannula and steel needle.
overtape
If infusion set sites are falling off early, use alcohol to clean the skin and remove oils. You can also consider Skin-Tac or “overtape.”
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Avoid insertion sites near creases and folds, or in areas where tight clothes and waist bands may rub on the infusion set.
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If the infusion set is leaking insulin, ensure that it is being changed at least every two to three days. Consider switching to a longer cannula length.
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For unexplained hyperglycemia that does not improve with correction boluses, immediately change the infusion set and check for ketones. “When in doubt, change it out!”
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Did you know that Tandem has a Clinical Support Services team?

If you have clinical needs and concerns you can speak with a Certified Diabetes Care and Education Specialist (CDCES) by calling 877-801-6901. Our team of experienced CDCESs will troubleshoot infusion set issues, provide guidance and suggestions to overcome concerns, and also send samples of alternate infusion sets when medically indicated.

Important Safety Information: RX ONLY. The t:slim X2 insulin pump with interoperable technology is an alternate controller enabled (ACE) pump that is intended for the subcutaneous delivery of insulin, at set and variable rates, for the management of diabetes mellitus in people requiring insulin. The pump is able to reliably and securely communicate with compatible, digitally connected devices, including automated insulin dosing software, to receive, execute, and confirm commands from these devices. The pump is indicated for use in individuals six years of age and greater. The pump is intended for single patient, home use and requires a prescription. The pump is indicated for use with U-100 insulin only. Users of the pump must: be willing and able to use the insulin pump and all other system components in accordance with their respective instructions for use; test blood glucose levels as recommended by their healthcare provider; demonstrate adequate carb-counting skills; maintain sufficient diabetes self-care skills; see healthcare provider(s) regularly; and have adequate vision and/or hearing to recognize all functions of the pump, including alerts. The t:slim X2 pump, and the CGM transmitter and sensor must be removed before MRI, CT, or diathermy treatment. Visit tandemdiabetes.com/safetyinfo for additional important safety information.

Infusion Sets: RX ONLY. These infusion sets are indicated for the subcutaneous infusion of insulin administered by the t:slim X2 insulin pump for the treatment of diabetes. These infusion sets are indicated for single use. For contraindications, warnings, precautions, and other important information, please refer to the instructions for use accompanying the infusion sets.

©2025 Tandem Diabetes Care, Inc. All rights reserved. Tandem Diabetes Care, the Tandem logo, AutoSoft, TruSteel, VariSoft, and t:slim X2 are either registered trademarks or trademarks of Tandem Diabetes Care, Inc. in the United States and/or other countries. All third-party marks are the property of their respective owners. CM-002480_A

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